It is human nature to try to recognize patterns and to make sense of that which we observe. Unfortunately, our intuition is often wrong, and so there is a need to impose some objectivity on the methods by which observations are converted into knowledge. One definition of biostatistics could be precisely this, the rigorous and objective conversion of medical and/or biological observations into knowledge. Both consumers of biostatistical principles and biostatisticians themselves vary in the extent to which they recognize the (...) need to continue the improvement. Some may not recognize the need for (some or all of) the methods that have already been developed; others may accept these as they find them completely sufficient; still others recognize both the value and the shortcomings of these methods, and seek to develop even better methods to ensure that future medical conclusions are less subject to biases than current ones are. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:SACRAMENTAL THEOLOGY: A METHODOLOGICAL PROPOSAL KEVIN w. IRWIN The Catholic University of America Washington, D.O. HE PAST DEOADE has witnessed the publication of number of English language works on sacraments ealing with general theories of sacramental theology as well as specialized studies of individual sacraments. In the postoonciliar church there is not yet a uniform or universally agreed upon method for the study of sacraments. Still most vecerrt 'Wo11ks (...) indicate significant shifts in method from the post-Tr:identine!legacy o:f treating sacraments priimarily in dogmatic tracts and canon law studies.1 At the s1ame time there has been an increased interest by liturgists and theologians alike in liturgical theology. This includes not only the theologicrul dimensions of what occurs in the liturgy hut 1also (more recently) how the liturgy can serve as a source for theology in geneml as well 1as for the theology of the sacraments.2 Despite this recent writing and evolving thought on the rela1 See, Kevin W. Irwin, "Recent Sacramental Theology: A Review Discus· sion," The Thomist 47 (1983) : 592-608; "Recent Sacramental Theology [Review Discussion II]" The Thomist 52 (1988) : 124-147; "Recent Sacramental Theology III," The Thomist 53 (1989) : 281-313. 2 Among the English language works that have sparked interest in liturgical theology and have shaped part of the contemporary deb-ate about what it includes are those of Aidan Kavanagh, On Liturgical Theology (New York: Pueblo, 1984) and Geoffrey Wainwright, Doxology: The Praise of God in Worship, Doctrine and Life (New York: Oxford University Press, 1980). For an assessment of these works and other recent writing on liturgical theology see Teresa Berger, "'Doxology,' 'Jubilate,' 'Liturgical Theology ': Zurn Verhaltnis von Liturgie und Theologie: Publikationen aus dem englischsprachen Raum,'' Arohiv fur Liturgiewissensohaft 28 (1986) : 247-255. 311 KEVIN W. IRWIN tionship of liturgy and sacramental theology, what is still lacking is some method for developing a contemporary theology of the sacraments with the liturgy as its foundation. There are many reasons for this lack: shifts in contemporary theological method in general, the nature of the reformed liturgy which invites flexibility and option, and :finally questions of wha;t ought to be factol'ed into a systemat1c study of the sacramental theology and of sacramental life in the postconciliar church. It is the purpose of this article to propose 1a, method for sacramental theology which uses liturgy as its essentia1l foundation and which delineates aspects of sacriamental theology 1that can be based on the liturgy. The article will be divided into ctwo unequal parts, with the :first laying the foundation for the second. The first deals with the general notion of a liturgical theology of the sacraments, with particular 1attention to the postconciliar context for this discussion.3 This foundation leads to the seoond pa:rt which proposes aspects of sacramental theology that are first drnwn from the liturgy and then can he used to understand 1both individual sacraments and sacraments in general hy continual reference to the liturgy. In delineating these aspects of a liturgically grounded sacramental theology, the categories of classical sacramental theology will be respected, in the sense that, despite their deficiencies, systematic treatises on 'Sacraments from the medieval and post-Tr,identine s This is not to suggest that the seminal works of such authors as Cipriano Vagaggini, Theological Dimensions of the Liturgy, trans. Leonard J. Doyle and W. A. Jurgens from the fourth Italian edition (Collegeville: The Litur· gical Press, 1976) and Alexander Schmemann, Introduction to Liturgical Theology, trans. Ashleigh Moorhouse (London: The F'aith Press, 1966), will be ignored. It is to suggest, however, that the recent work on liturgical theology has had to consider the flexibility of postconciliar liturgy as opposed to the fixity of the preconciliar rites. On this as an important factor in the method of doing liturgical theology see P. DeC!erck, "Lex orandi, lex oredendi, sens original et avatars historiq'ues d'un adage equivoque," Questions Liturgiques 59 (1978) : 193-212, and Gerarcl Lukken, "La liturgic comme lieu theologique irremplacable," Questions Liturgiques 56 (1975) : 104-109. SACRAM:ENTAL THEOLOGY 313 periods have left a v:aluable legacy of sacramental theory and prractice.4 The following six aspects of the liturgical experience... (shrink)

A number of nonmonotonic reasoning formalisms have been introduced to model the set of beliefs of an agent. These include the extensions of a default logic, the stable models of a general logic program, and the extensions of a truth maintenance system among others. In [13] and [16], the authors introduced nonmonotomic rule systems as a nonlogical generalization of all essential features of such formulisms so that theorems applying to all could be proven once and for all. In this paper, (...) we extend Rieter's normal default theories, which have a number of the nice properties which make them a desirable context for belief revision, to the setting of nonmonotonic rule systems. Reiter defined a default theory to be normal if all the rules of the default theory satisfied a simple syntatic condition. However, this simple syntatic condition has no obvious analogue in the setting of nonmonotonic rule systems. Nevertheless, an analysis of the proofs of the main results on normal default theories reveals that the proofs do not rely on the particular syntactic form of the rules but rather on the fact that all rules have a certain consistency property. This led us to extend the notion of normal default theories with respect to a general consistency property. This extended notion of normal default theories, which we call Forward Chaining normal , is easily lifted to nonmonotomic rule systems and hence applies to general logic programs and truth maintenance. (shrink)

This book is a collection of Rush Rhees' recent articles on Wittgenstein along with a record of Wittgenstein's comments on continuity made in private conversations in 1938. The first part of the book is on the Tractatus. It begins with a review of Anscombe's Introduction of which Rhees generally approves and then goes on to discuss the "picture theory" and language's capacity to get hold of reality. Rhees argues against Maslow that elementary statements are more than psychological phenomena but must (...) be spoken of in a purely formal sense. Commenting on Black's Companion he argues that Wittgenstein did not have in mind any ontological implications of logic when he was working on the Tractatus. Rhees uses his critique of Pitcher's Philosophy of Wittgenstein and an article on that philosophy to form the transition to the discussion of the later Wittgenstein. He insists that Wittgenstein taught more a method of seeing the depth of certain problems than a set of solutions to those problems. He introduces the theme of "publicness" by arguing that language involves the ability to "say something" and must thus involve publicity. In his article on "Wittgenstein's Builders" he argues that this ability to say something rests on the interrelation of language games and the unity of a form of life. Using this as a basis, he speaks of the Wittgensteinean approach to ethics as one of studying the way of saying something ethically in a certain language game rather than one of studying ethics in general. The essay on continuity begins with a discussion of the dependence of mathematical language on everyday language for meaning. Here Wittgenstein argues that mathematical language derives its sense from experiential language and not from eternal and immutable objects. He discusses the mathematical notion of continuity with an eye to the limits of its sense and shows that its sense is limited by ordinary notions of space and continuity and tests relating to them. This book is worth reading for both the presentation of basic approaches to understanding Wittgenstein and for the record of Wittgenstein's remarks on continuity which are unavailable elsewhere.--J. V. W. (shrink)

One of Anchor books, new Problems in Philosophy Series, this slim and simple volume gives a clear yet comprehensive account of the mind-body problem and its various solutions. Campbell brings to light the assumptions which lead to the mind-body problem, and examines each in terms of the evidence for it and the way it is handled in some of the solutions to the problem. He then formulates the basic mind-body problem as an inconsistent tetrad and examines the evidence upon which (...) each of the four propositions has been accepted at one time or another. After this preliminary study, Campbell examines two Dualisms and their solutions, the Behaviorist 'solution' or dissolution, and different forms of a Causal Theory of the Mind, including Central State Materialism and what he calls a 'new Epiphenomenalism'. In his examination of these solutions to the problem, Campbell always states both the reasons for accepting it and the problems that the solution itself raises. Not intended for a sophisticated audience, this lucid account will provide the beginner with a solid basis for further studies in this central problem. With this in mind, the author has included an extensive bibliography for the beginning student.--W. de V. (shrink)

Subtitled "Rejections of Cartesian Dualism" this collection of essays traces through western Philosophy the strong but often overlooked idea that the body and the mind are not two different kinds of entity somehow reconciled in man, but rather a unity that is man. The editor's introduction sets forth Aristotle's ideas, concentrating on the dictum that it is the same man that thinks and runs. Spicker also treats Descartes' view, and the view of the Cartesians, ably separating the two when necessary. (...) The rest of the book is basically arranged chronologically, starting with extracts from Spinoza's Ethics, an essay on these extracts by Hans Jonas, and then moving through Julien de la Mettrie and two short essays by Kant. The second part of the book contains interesting essays on the human body by John Dewey, Douglas Long, and B. A. O. Williams, all defending the essential unity of body and soul. The third and last section of the book is itself divided into two parts, the first of which, entitled "Philosophy of Embodiment" contains four extracts from the works of prominent phenomenologists, Max Scheler, Gabriel Marcel, Jean-Paul Sartre, and Maurice Merleau-Ponty. These essays all center around the necessity of a concept of the "lived body" to the understanding of man's being-in-the-world. In the last section, the quality of the essays drops, although it is delightfully leavened by a witty essay by Richard Griffith on the foot. This section contains essays on particular parts of the human body, such as sight and the upright posture, by Herbert Plügge, Hans Jonas, and Erwin W. Straus. There is a selected bibliography for those who are captured by this basic thread of western thought.--W. A. de V. (shrink)

Patient centred diagnosis is best practised through shared decision making; an iterative dialogue between doctor and patient, whichrespects a patient’s needs, values, preferences, and circumstances. -/- Shared decision making for diagnostic situations differs fundamentally from that for treatment decisions. This has important implications when considering its practical application. -/- The nature of dialogue should be tailored to the specific diagnostic decision; scenarios with higher stakes or uncertainty usually require more detailed conversations.

An estimated 700,000 people in the United States have "long COVID," that is, symptoms of COVID-19 persisting beyond three weeks. COVID-19 and its long-term sequelae are strongly influenced by social determinants such as poverty and by structural inequalities such as racism and discrimination. Primary care providers are in a unique position to provide and coordinate care for vulnerable patients with long COVID. Policy measures should include strengthening primary care, optimizing data quality, and addressing the multiple nested domains of inequity.

This dissertation seeks to contribute to research in the philosophy of social science. The study focuses upon select epistemological and ontological aspects of Hannah Arendt’s work from which methodological implications are drawn pertaining to sociology. Arendt, although critical of the sociology of her time, has become increasingly cited and influential for emerging sociological research and this study seeks to contribute to this by focusing upon the problem of novelty. The aim is to explore the philosophical and methodological implications of novelty (...) for social science by working through three case studies that are theoretically pivotal for social science—action, the ‘social’, and the self—in terms of novelty as expressed in Arendt’s writing. Arendt is critical of methodology and epistemology, aiming to draw her readers to ontological concerns outlined from her preoccupation with the 'world' and social reality. In this aim, Arendt seeks to distance herself from social sciences that she claims ignore human novelty in favour of reading social regularities, tendencies and similarities. Despite her disdain for method, Arendt suggests a anti-methodological 'method' (outlined in an overlooked footnote) for keeping trained upon and for dealing with novel, anomalous events. In the seed of this method lies a unique opportunity for social science to reassess and extend its methods, addressing this oversight and in so doing bring to light the novel social object as a legitimate subject of social research. (shrink)

Calpains are a family of calcium‐dependent thiol‐proteases which are proposed to be involved in many physiological processes as well as pathological conditions. Calpains are likely to be involved in processing of numerous enzymes and cytoskeletal components, thereby linking their activity to a variety of intracellular events. Although widely studied, the precise mechanism(s) involved in calpain activation and activity in vivo remain poorly understood. Initial studies suggested that calpain exists primarily as an inactive proenzyme that required autolytic cleavage for activation. It (...) was also hypothesized that calpain associated with membrane phospholipids, serving to increase calcium sensitivity, facilitating autolytic conversion and thus activating the enzyme. These hypotheses, however, have not been universally accepted and there is increasing evidence that intact, non‐autolyzed calpain is the physiologically active calpain form. (shrink)

Over the last decades, it has become evident that highly complex networks of regulators govern post‐transcriptional regulation of gene expression. A novel class of Argonaute (Ago)‐associated RNA molecules, the agotrons, was recently shown to function in a Drosha‐ and Dicer‐independent manner, hence bypassing the maturation steps required for canonical microRNA (miRNA) biogenesis. Agotrons are found in most mammals and associate with Ago as ∼100 nucleotide (nt) long RNA species. Here, we speculate on the functional and biological relevance of agotrons: (i) (...) agotrons could serve as non‐promiscuous miRNA‐like regulators with reduced off‐targeting or (ii) agotrons could encompass other putative functions, such as protecting Ago proteins from taking up aberrant short RNAs or by rescuing and stabilizing otherwise unloaded Ago‐proteins from degradation. Collectively, agotrons have emerged as a novel class of interesting non‐coding RNA molecules, but their full functional potential and biological impact still remain to be disclosed. (shrink)

Recently a great deal of attention has been paid to conflicts of interest in medical research, and the Institute of Medicine has called for more research into this important area. One research question that has not received sufficient attention concerns the mechanisms of action by which conflicts of interest can result in biased and/or flawed research. What discretion do conflicted researchers have to sway the results one way or the other? We address this issue from the perspective of selective inertia, (...) or an unnatural selection of research methods based on which are most likely to establish the preferred conclusions, rather than on which are most valid. In many cases it is abundantly clear that a method that is not being used in practice is superior to the one that is being used in practice, at least from the perspective of validity, and that it is only inertia, as opposed to any serious suggestion that the incumbent method is superior, that keeps the inferior procedure in use, to the exclusion of the superior one. By focusing on these flawed research methods we can go beyond statements of potential harm from real conflicts of interest, and can more directly assess actual harm. (shrink)

WALTER BURLEIGH, Von der Reinheit der Kunst der Logik. Erster Traktat: Von den Eigenschaften der Termini. Übersetzt und mit Einfuhrung und Anmerkungen herausgegeben von Peter Kunze. Lateinisch-deut...

: Two major philosophers of the twentieth century, the German existential phenomenologist Martin Heidegger and the seminal Japanese Kyoto School philosopher Nishida Kitarō are examined here in an attempt to discern to what extent their ideas may converge. Both are viewed as expressing, each through the lens of his own tradition, a world in transition with the rise of modernity in the West and its subsequent globalization. The popularity of Heidegger's thought among Japanese philosophers, despite its own admitted limitation to (...) the Western "history of being," is connected to Nishida's opening of a uniquely Japanese path in its confrontation with Western philosophy. The focus is primarily on their later works (the post-Kehre Heidegger and the works of Nishida that have been designated "Nishida philosophy"), in which each in his own way attempts to overcome the subject-object dichotomy inherited from the tradition of Western metaphysics by looking to a deeper structure from out of which both subjectivity and objectivity are derived and which embraces both. For Heidegger, the answer lies in being as the opening of unconcealment, from out of which beings emerge, and for Nishida, it is the place of nothingness within which beings are co-determined in their oppositions and relations. Concepts such as Nishida's "discontinuous continuity," "absolutely self-contradictory identity" (between one and many, whole and part, world and things), the mutual interdependence of individuals, and the self-determination of the world through the co-relative self-determination of individuals, and Heidegger's "simultaneity" (zugleich) and "within one another" (ineinander) (of unconcealment and concealment, presencing and absencing), and their "between" (Zwischen) and "jointure" (Fuge) are examined. Through a discussion of these ideas, the suggestion is made of a possible "transition" (Übergang) of both Western and Eastern thinking, in their mutual encounter, both in relation to each other and each in relation to its own past history, leading to both a self-discovery in the other and to a simultaneous self-reconstitution. (shrink)

We typically think of prosecutorial ethics as encompassing a special set of obligations for prosecutors during the pretrial and trial stages of a criminal case. In the literature and in rules of professional responsibility much attention is paid to the charging function, contact with unrepresented persons, plea negotiations, discovery, and courtroom decorum. Our concern with prosecutorial ethics at these stages is rooted primarily in due process and fairness to the accused. [W]hile he may strike hard blows, the Supreme Court wrote (...) in Berger v. United States, [a prosecutor] is not at liberty to strike foul ones. Whether it is a recognition that the prosecutor acts as a representative of the sovereign or that he or she possesses extraordinary power over people's lives, we speak about the prosecutor's ethical duties as special or additional to those of ordinary lawyers. By preventing a prosecutor from litigating unfairly, the aim is to protect a criminal defendant from an unjust or unwarranted conviction. What, then, are the ethical duties of prosecutors after the defendant has had his fair shot at trial, but lost? The literature and standards are surprisingly silent, with rare exception, on the post-conviction ethics of prosecutors. Constraints on the prosecutorial function seem to reach their apex at trial. Why? Are the reasons for special or additional ethics for prosecutors non-existent on appeal? Is the vast discretion, present at the pretrial and trial stages and thought by some to justify special ethical duties, absent on appeal? As a recent case from Texas illustrates, ethical issues still abound even after a jury returns a verdict of guilty. Nevertheless, the traditional discourse on pre-conviction duties can help us determine how prosecutorial discretion should be exercised after a conviction has been obtained. (shrink)

With his customary incisiveness, W. V. Quine presents logic as the product of two factors, truth and grammar--but argues against the doctrine that the logical truths are true because of grammar or language. Rather, in presenting a general theory of grammar and discussing the boundaries and possible extensions of logic, Quine argues that logic is not a mere matter of words.

Things and Their Place in Theories Our talk of external things, our very notion of things, is just a conceptual apparatus that helps us to foresee and ...

This book is a translation of W.V. Quine's Kant Lectures, given as a series at Stanford University in 1980. It provide a short and useful summary of Quine's philosophy. There are four lectures altogether: I. Prolegomena: Mind and its Place in Nature; II. Endolegomena: From Ostension to Quantification; III. Endolegomena loipa: The forked animal; and IV. Epilegomena: What's It all About? The Kant Lectures have been published to date only in Italian and German translation. The present book is filled out (...) with the translator's critical Introduction, "The esoteric Quine?" a bibliography based on Quine's sources, and an Index for the volume. (shrink)

Our only channel of information about the world is the impact of external forces on our sensory surfaces. So says science itself. There is no clairvoyance. How, then, can we have parlayed this meager sensory input into a full-blown scientific theory of the world? This is itself a scientific question. The pursuit of it, with free use of scientific theory, is what I call naturalized epistemology. The Roots of Reference falls within that domain. Its more specific concern, within that domain, (...) is reference to concrete and abstract objects: what such reference consists in, and how we achieve it. (shrink)